The Upstate is the region in the westernmost part of South Carolina, United States, also known as the Upcountry, which is the historical term. Situated between Atlanta and Charlotte, the Upstate is the geographical center of the Charlanta mega-region. Wikipedia

The Midlands region of South Carolina is the middle area of the state. The region's main center is Columbia, the state's capital. The Midlands is so named because it is halfway point between the Upstate and the Lowcountry. Wikipedia

The Pee Dee is a region of South Carolina located in the northeastern corner of the state. It lies along the lower watershed of the Pee Dee River, which was named after the Pee Dee Native Tribe, a state-recognized tribe of approximately 200 members. Wikipedia

The Lowcountry (sometimes Low Country or just low country) is a geographic and cultural region along South Carolina's coast, including the Sea Islands. There are several variations on the geographic extent of the Lowcountry area. The most commonly accepted definition includes the counties of Beaufort, Colleton, Hampton, and Jasper; often described as the area between the Savannah and Ashley Rivers. Wikipedia